CV Dr. Josep Mª Argilés

Personal data


Surname and name: Argilés, Josep M.
Work address: Departament de Bioquímica i Biología Molecular, Unitat B, Facultat de Biologia, Universitat de   Barcelona, Diagonal 645, 08071-Barcelona, Spain
Telephone: 34-93-4021002; Telefax: 34-93-4021559; 
e-mail: argiles@porthos.bio.ub.es


Academic Degrees


Diploma in Computing Science,  University of Barcelona, 1977
Licenciado in Biology, University of Barcelona, 1978
Doctor in Biochemistry,  University of Barcelona, 1981


Prizes and Disctintions


First Class Degree and Extraordinary Prize for the best B.Sc. (Biology), 1979
Extrordinary Prize for the best Ph.D. Degree, 1981
Divulga Prize of the Science Museum, 1985
City of Barcelona Science Award, 1997
International Award, IJO, 2002


Academic Posts


1978-1981  Assistant Lecturer in Biochemistry, University of Barcelona
1981-1986  Lecturer in Biochemistry, University of Barcelona
1986- now   Professor of Biochemistry and Molecular Biology of Cancer, University  of Barcelona


International Posts


1986  Invited Lecturer, National Institute of Health, Bethesda, U.S.A.
1987  Research Associate, University of Oxford, U.K.
1988  Invited Scientist, University of Minnesota, U.S.A.


Evaluation Committies


Scientific journals


Journal of Chromatography, Medicina Clínica, Journal of Clinical Investigation, Comparative Biochemistry and Physiology, European Journal of Cancer, European Cytokine Network, British Journal of Cancer, American Journal of Physiology, Biochimica et Biophysica Acta, Clinical Science, International Journal of Biochemistry and Cell Biology, Oncology Research, Cancer Research, Experimental Cell Research, FASEB Journal, Clinical Nutrition, Oncology, Nutrition and Cancer, Cancer Letters, Journal of Nutrition, Journal of Pharmacy and Pharmacology, Biochemical Pharmacology, The Lancet. Clinical Physiology and Functional Imaging, International Journal of Cancer, American Journal of Pathology, Cell Biology International, Journal of Neurochemistry, American Journal of Pathology, Brazilian Journal of Medical and Biological Research, FEBS Letters, Clinical Cancer Research, Current Drug Targets, Breat cancer Research, Journal of Surgical Research, Nature Biotechnology, CRC Press (Books), Gut, Muscle and Nerve, Physiology, Life sciences, Journal of Applied and Basic Nutritional Sciences, Journal of Immunological methods, Nutrition, BMC Cancer, Journal of Nutritional Biochemistry, Molecular and Cellular Biochemistry, Chemotherapy, Obesity, Lancet Oncology, Drug Design and Discovery, Pharmacology and Therapeutics, Current Nutrition and Food Science, Lung Cancer, European Journal of Endocrinology, Journal of Molecular Medicine, Expert Opinion on Investigational Drugs, Journal of Applied Physiology, Molecular Nutrition and Food Research, Neuroendocrinology, Proceedings of the National Academy of Sciences USA (PNAS), Journal of Diabetes and its Complications, Expert Reviews in Molecular Medicine, BMC Palliative Care, Journal of Cellular and Molecular Medicine, Expert Opinion on Therapeutic Patents, European Journal of Clinical Investigation, Apoptosis, Archives of Medical Research,  Journal of Clinical Oncology, Cell Bochemistry and Function, Molecular Diagnosis and Therapy, Mitochondrion, Acta Physiologica, Clinical Lung Cancer, Tumori. Journal of Medicinal Food.


Research Organizations


CIRIT (Spain), ANEP (Spain), European Union (DG XII), Wellcome Trust (United Kingdom),  Fundaçao de Amparo a Pesquisa do Estado de Såo Paolo, (Brasil), Austrian Science Foundation (Austria), Asociacion Française contre les Myopathies, (France), Killam Foundation (Canada). Natural Sciences and Engineering Research Council (Canada), Associacione Italiana per la recerca sul Cranco (Italy), Cancer Research UK (United Kingdom), FONICYT (Argentina),  Slovak Research and Development Agency (Slovenia), Fundación Progreso y Salud (Spain), Diabetes-UK (UK), Natural Sciences and Engineering Research Council (Canada), Israel Science Foundation (Israel).




Present Courses under his supervision


Biochemistry
Advanced Biochemistry and Regulation of Metabolism
Biochemistry of Cancer
Cytokines




Present research area and scientific team


Biochemistry of cancer.  Head of a Research group consisting of 3 Ph.D students and 2 post-doctoral research associates.



List of publications



1) Argilés, J.M. & Herrera, E. 
Efecte de la insulina sobre la utilització de les lipoproteïnes de molt baixa densitat (VLDL) per teixits extra-hepàtics a la rata "in vivo".
Annals de Medicina  66: 1007-1013 (1980). (A)

2) Argilés, J.M. 
Algunos aspectos del metabolismo de las lipoproteínas plasmáticas en la rata.
Publicaciones de la Universidad de Barcelona  (1981). (A)

3) Argilés, J.M. & Herrera, E.
Lipid and lipoproteins in maternal and fetus plasma in the rat.
Biology of the Neonate  39: 37-44 (1981). (A)

4) Argilés, J.M. & Herrera, E.
Changes in lipid composition of plasma lipoproteins after total hepatectomy in the rat.
Archives Internationales de Physiologie et Biochimie  89: 461-465 (1981). (A)

5) Argilés, J.M. & Herrera, E. 
Effect of insulin on the disposal of 14C-labelled very low density lipoprotein triglycerides in intact and hepatectomized rats.
Diabetologia  24: 300-303 (1983). (A)

6) Espinet, C. & Argilés, J.M.
The use of thiourea in the determination of tissue ethanol and acetaldehyde concentrations.
IRCS Medical Science  12: 291-292 (1984). (A)

7) Espinet, C. & Argilés, J.M.
Ethanol and acetaldehyde levels in rat blood and tissues after an acute ethanol administration.
IRCS Medical Science  12: 830-831 (1984). (A)

8) Espinet, C. & Argilés, J.M.
Ethanol and acetaldehyde concentrations in the rat foeto-maternal system after an acute ethanol administration given to the mother.
Archives Internationales de Physiologie et Biochimie  92: 339-344 (1984). (A)

9) López-Soriano, F.J. & Argilés, J.M. 
Acetone levels in rat plasma and tissues: effect of pregnancy and fasting.
IRCS Medical Science  13: 161-162 (1985). (A)

10) López-Soriano, F.J. & Argilés, J.M.
A simple method for the preparation of acetoacetate.
Analytical Letters  18: 589-592 (1985). (A)

11) López-Soriano, F.J. & Argilés, J.M.
Simultaneous determination of ketone bodies in biological samples by gas chromatographic headspace analysis.
Journal of Chromatographic Science  23: 120-123 (1985). (A)

12) Argilés, J.M.
La obesidad, un problema social de origen molecular.
Ibérica  265: 125-128 (1985). (A)

13) Espinet, C. & Argilés, J.M.
The utilization of disulfiram in the determination of acetaldehyde concentrations in rat plasma.
IRCS Medical Science  13: 50 (1985). (A)

14) Argilés, J.M. & Rich, P.
The gap-filling technique in biochemistry.
Biochemical Education  13: 122-123 (1985). (A)

15) López-Soriano, F.J., Alemany, M. & Argilés, J.M.
  Rat acetoacetic acid decarboxylase inhibition by acetone.
International Journal of Biochemistry  17: 1271-1273 (1985). (A)

16) Argilés, J.M.
Has acetone a role in the conversion of fat to carbohydrate in mammals?
Trends in Biochemical Sciences  11: 61-63 (1986). (A)

17) López-Soriano, F.J. & Argilés, J.M.
Rat acetoacetate decarboxylase: its role in the disposal of 4C-ketone bodies by the fetus.
Hormone and Metabolic Research  18: 446-449 (1986). (A)

18) López-Soriano, F.J., Alemany, M. & Argilés, J.M.
Is there a metabolic role for acetone in mammals?
Speculations in Science and Technology  9: 219-220 (1986). (A)

19) López-Soriano, F.J. & Argilés, J.M. 
On the role of 2,3-butanediol in the metabolism of ethanol.
Medical Hypotheses  20: 179-181 (1986). (A)

20) Peinado, J., López-Soriano, F.J. & Argilés, J.M.
The levels of 2,3-butanediol in acetone-injected rats: effects of pregnancy and fasting.
Biochemical Archives  2: 159-163 (1986). (A)

21) Rivera, S., Azcón-Bieto, J., López-Soriano, F.J. & Argilés, J.M. 
Blood amino acid compartmentation and activities of enzymes of amino acid metabolism in mice.
Biochemical Society Transactions  14: 1052-1053 (1986). (A)

22) Argilés, J.M.
A simple rule for the conversion of Fischer monosaccharide projection formulae into Haworth representations. 
Journal of Chemical Education  63: 927-928 (1986). (A)

23) Espinet, C. & Argilés, J.M.
  Effects of temperature and storage time on acetaldehyde concentrations in plasma samples.
IRCS Medical Science  14: 1083-1084 (1986). (A)

24) López-Tejero, D., López-Soriano, F.J. & Argilés, J.M.
The appearance of 2,3-butanediol in the chronic ethanol-treated pregnant rat.
Drug and Alcohol Dependance  18: 335-339 (1986). (A) 

25) Prats, E., Monfar, M., Argilés, J.M. & Alemany, M.
  Energetic homeostasis in cafeteria rats subjected to 24 hours of food deprivation.
Journal of Obesity and Weight Regulation  5: 77-88 (1986) (A)

26) Peinado, J., López-Soriano, F.J. & Argilés, J.M.
The metabolism of acetone in the pregnant rat. 
Bioscience Reports  6: 983-989 (1986). (A)

27) Argilés, J.M. 
Papel de los cuerpos cetónicos en el feto.
"Bioquímica Perinatal" (editor: E. Herrera). Fundación Ramón Areces, pp. 213-228 (1986). (CL)


28) Argilés, J.M. & López-Soriano, F.J.
Las armas bioquímicas de los seres vivos.
Mundo Científico  57: 444-450 (1986). (A)

29) Argilés, J.M. & López-Soriano, F.J.
La termorregulación en los Mamíferos.
Publicaciones del Museu de la Ciència (1986).


30) Prats, E., Monfar, M., Argilés, J.M. & Alemany, M.
Effects of starvation and a high-energy diet on rat blood compartmentation of injected radioactive alanine and glucose.
Biochemistry International  14: 95-101 (1987). (A)

31) Peinado, J., López-Soriano, F.J. & Argilés, J.M.
Gas chromatographic method for the estimation of acetone and its metabolites in biological samples.
Journal of Chromatography  415: 372-376 (1987). (A)

32) Monfar, M., Prats, E., Argilés, J.M. & Alemany, M.
Global utilization of injected alanine label in cafeteria-fed rats. Effect of 24 hours of starvation.
Biochemical Archives  3: 331-336 (1987). (A)

33) Rivera, S., López-Soriano, F.J., Azcón-Bieto, J. & Argilés, J.M. 
Blood amino acid compartmentation in mice bearing Lewis lung carcinoma.
Cancer Research  47: 5644-5646 (1987). (A)

34) Monfar, M., Prats, E., Argilés, J.M. & Alemany, M.
  A 24-hour fast-induced loss of energetic substrates in the interscapular brown adipose tissue of "cafeteria" rats.
Nutrition Research  7: 871-876 (1987). (A)

35) Argilés, J.M. & Borrell, C.
Las consecuencias metabólicas de la contaminación por mercurio.
Ibérica 289:  299-303, 1987 (A)


36) Rivera, S., Azcón-Bieto, J., López-Soriano, F.J. Miralpeix, M. & Argilés, J.M.
Amino acid metabolism in tumor-bearing mice.
Biochemical Journal  249: 443-449 (1988). (A)

37) Prats, E., Monfar, M., Argilés, J.M. & Alemany, M.
  Effects of a cafeteria diet and starvation on global 14C(U)-glucose disposal.
Biochemistry International  17: 35-49 (1988). (A)

38) Argilés, J.M. & Azcón-Bieto, J.
The metabolic environment of cancer.
Molecular and Cellular Biochemistry  81: 3-17 (1988). (R)

39) Domènech, T., Rafecas, I., Esteve, M., Argilés, J.M. & Alemany, M.
  A sensitive direct calorimeter for small mammals.
Journal of Biochemical and Biophysical Methods  17: 35-42 (1988). (A)

40) Casado, F.J., Fernández-López, J.A., Argilés, J.M. & Alemany, M. 
A nondestructive method for the measurement of radioactive 14CO2 in blood.
Analytical Biochemistry  172: 509-513 (1988). (A)


41) Argilés, J.M.
  The rise and fall of the cafeteria diet: some observations.
Journal of Nutrition  118: 1593-1594 (1988). (A)

42) Argilés, J.M.
Metabolismo de los cuerpos cetónicos en el feto.
"Bioquímica Perinatal: Aspectos Patológicos" (editor: E. Herrera). Fundación Ramón Areces, pp. 347-366 (1988). (CL)


43) Miralpeix, M., Rivera, S., Argilés, J.M. & Azcón-Bieto, J.
The respiratory behaviour of Lewis carcinoma cells. Existence of a cyanide-resistant respiration.
Cancer Biochemistry and Biophysics  10: 227-233 (1989). (A)

44) Argilés, J.M. & Herrera, E.
Appearance of circulating and tissue 14C-lipids after oral 14C-tripalmitate administration in the late pregnant rat.
Metabolism  38: 104-108 (1989). (A)

45) Argilés, J.M.
The obese Zucker rat: a choice for fat metabolism. 
Progress in Lipid Research  28: 53-66 (1989). (R)

46) Argilés, J.M., López-Soriano, F.J., Evans, R.D. & Williamson, D.H.
Interleukin-1 and lipid metabolism in the rat.
Biochemical Journal  259: 673-678 (1989). (A)

47) Argilés, J.M., López-Soriano, F.J., Wiggins, D. & Williamson, D.H.
Comparative effects of tumour necrosis factor-a (cachectin), interleukin-1-b, and tumour growth on amino acid metabolism in the rat in vivo.
Biochemical Journal  261: 357-362 (1989). (A)

48) Evans, R.D., Argilés, J.M. & Williamson, D.H. 
Metabolic effects of tumour necrosis factor-a (cachectin) and interleukin-1.
Clinical Science  77: 357-364 (1989). (R)

49) Argilés, J.M.
  The oxidation of methylglyoxal by mammalian pyruvate dehydrogenase.
Archives of Biochemistry and Biophysics  273: 238-244 (1989). (A)

50) Argilés, J.M. & López-Soriano, F.J. 
Las citoquinas: defensa del huésped contra la infección y el cáncer.
Mundo Científico  9: 988-993 (1989). (A)

51) Argilés, J.M. & López-Soriano, F.J.
  Oxidation of branched-chain amino acids in tumour-bearing rats.
Biochemical Society Transactions  17: 1044-1045 (1989). (A)

52) Argilés, J.M. & López-Soriano, F.J.
  Effects of tumour necrosis factor on hepatic amino acid uptake.
Biochemical Society Transactions  17: 1045-1046 (1989). (A)

53) Argilés, J.M. & López-Soriano, F.J.
  The effects of tumour necrosis factor-a (cachectin) and tumour growth on hepatic amino acid utilization in the rat.
Biochemical Journal  266: 123-126 (1990). (A)

54) Argilés, J.M. & López-Soriano, F.J.
  Las bases moleculares de la caquexia asociada al cancer.
Medicina Clínica  94: 18-20 (1990). (R)

55) Rafecas, I., Domènech, T., Esteve, M., Remesar, X., Argilés, J.M. & Alemany, M. 
The thermogenic effect of a sucrose gavage on the fa/fa rat.
Nutrition Research  9: 1407-1413 (1990). (A)

56) Argilés, J.M. & López-Soriano, F.J.
  Why do cancer cells have such a high glycolytic rate? 
Medical Hypotheses  32: 151-155 (1990). (A)

57) Miralpeix, M., Azcón-Bieto, J., Bartrons, R. & Argilés, J.M.
  The impairment of respiration by glycolysis in the Lewis lung carcinoma.
Cancer Letters  50: 173-178 (1990). (A)

58) Argilés, J.M. & López-Soriano, F.J.
  The oxidation of leucine in tumour-bearing rats.
Biochemical Journal  268: 241-244 (1990). (A)

59) Argilés, J.M. & López-Soriano, F.J.
  Intestinal amino acid transport: an overview.
International Journal of Biochemistry  22: 931-937 (1990). (R)

60) Argilés, J.M., Fernández-López, J.A., Casado, J. & Alemany, M.
  Is there a role for lymph in intestinal glucose absorption?
Medical Hypothese  s  33: 169-171 (1990). (A)

61) Casado, J., Fernández-López, J.A., Esteve, M., Rafecas, I., Argilés, J.M. & Alemany, M.
Rat splanchnic net oxygen consumption: energy implications.
Journal of Physiology  431: 557-569 (1990). (A)

62) Argilés, J.M. & López-Soriano, F.J.
  The energy state of tumor-bearing rats.
Journal of Biological Chemistry  266: 2978-2982 (1991). (A)

63) López-Soriano, F.J., Carbó, N. & Argilés, J.M.
Lipid metabolism in the obese Zucker rat. Disposal of an oral [14C]triolein load and lipoprotein lipase activity.
Biochemical Journal  274: 651-656 (1991). (A)

64) Argilés, J.M. & López-Soriano, F.J.
  Cáncer y caquexia.
Clinica Rural  357: 14-23 (1991). (A)


65) Palet, A., Ribas-Carbó, M., Argilés, J.M. & Azcón-Bieto, J.
Short-term effects of carbon dioxide on carnation callus cell respiration. 
Plant Physiology  96: 467-472 (1991). (A)

66) Casado, J., Fernández-López, J.A., Esteve, M., Rafecas, I., Argilés, J.M. & Alemany, M.
Rat liver amino acid balances after the administration of an oral protein load.
Biochemistry International  25: 869-877 (1991). (A)


67) Carbó, N., López-Soriano, F.J. & Argilés, J.M.
  Effects of starvation on the tissular lipogenic rate in the obese Zucker rat.
Biochemistry International  24: 1043-1049 (1991). (A)

68) Argilés, J.M. & López-Soriano, F.J.
  The enzymatic activities of branched-chain amino acid catabolism in tumour-bearing rats.
Cancer Letters  61: 239-242 (1991) (A)


69) Carbó, N., López-Soriano, F.J. & Argilés, J.M.
Glucose handling by hepatocytes from obese Zucker rats.
Bioscience Reports  11: 285-292 (1991). (A)


70) Argilés, J.M., Zegrí, A., Arbós, J., García, C. & López-Soriano, F.J.
  The role of insulin in the intestinal absorption of glucose in the rat.
International Journal of Biochemistry  24: 631-636 (1992). (A)

71) Fernández-López, J.A., Casado, J., Rafecas, I., Esteve, M., Argilés, J.M. & Alemany, M.
Rat intestinal amino acid balances after the administration of an oral protein load.
Biochemistry International  26: 297-308 (1992). (A)

72) Domènech, M., López-Soriano, F.J., Carbó, N. & Argilés, J.M.
  Amino acid metabolism in several tissues of the obese Zucker rat as indicated by the tissue accumulation of a-amino[1-14C]isobutyrate 
  Molecular and Cellular Biochemistry  110: 155-159 (1992). (A)


73) Argilés, J.M., Zegri, A. & López-Soriano, F.J.
  The DDT method: an alternative to the use of radiolabelled microspheres for the determination of regional blood flows in the rat.
Medical Hypotheses  37: 268-270 (1992). (A)

74) Carbó, N., López-Soriano, F.J. & Argilés, J.M.
  Metabolism of glucose in isolated intestinal cells from obese Zucker rats.
Nutrition Research  12: 949-954 (1992). (A)


75) Domènech, M., López-Soriano, F.J., Carbó, N. & Argilés, J.M.
  The metabolic fate of an oral 14C-alanine load in the obese Zucker rat.
International Journal of Obesity  16: 213-218 (1992). (A)

76) Fernández-López, J.A., Casado, J., Argilés, J.M. & Alemany, M.
  In the rat, intestinal lymph carries a significant amount of ingested glucose into the bloodstream.
Archives Internationales de Physiologie et Biochimie  100: 231-236 (1992). (A)

77) Casado, J., Fernández-López, J.A., Argilés, J.M. & Alemany, M.
Role of the rat liver in the disposal of a glucose gavage.
Molecular and Cellular Biochemistry  113: 33-41 (1992). (A)

78) Fernández-López, J.A., Casado, J., Argilés, J.M. & Alemany, M.
Intestinal handling of a glucose gavage by the rat.
Molecular and Cellular Biochemistry  113: 43-53 (1992). (A)


79) Arbós, J., López-Soriano, F.J., Carbó, N. & Argilés, J.M.
Effects of tumour necrosis factor-a (cachectin) on glucose metabolism in the rat. Intestinal absorption and isolated enterocyte metabolism.
Molecular and Cellular Biochemistry  112: 53-59 (1992). (A) 


80) Argilés, J.M., García-Martínez, C., Llovera, M. & López-Soriano, F.J.
The role of cytokines in muscle wasting: its relation with cancer cachexia.
Medicinal Research Reviews  12: 637-652 (1992). (R)

81) Argilés, J.M., López-Soriano, J., Ortiz, M.A., Pou, A. & López-Soriano, F.J.
Interleukin-1 and b-cell function: more than one second messenger?
Endocrine Reviews  13: 515-524 (1992). (R)


82) Argilés, J.M., Carbó, N. & López-Soriano, F.J.
Hepatic accumulation of a-aminoisobutyrate in the pregnant rat at term.
Biochemistry International  28: 199-204 (1992). (A)

83) Argilés, J.M., Llovera, M. & López-Soriano, F.J.
Creixement tumoral i metabolisme de l'hoste: dues cares d'una mateixa moneda.
Treballs de la Societat Catalana de Biologia  43: 51-80 (1992). (A)

84) García-Martínez, C., López-Soriano, F.J. & Argilés, J.M.
Intestinal glucose absorption is lower in obese than in lean Zucker rats.
Journal of Nutrition  123: 1062-1067 (1993). (A)


85) Domènech, M., López-Soriano, F.J., Marzábal, M. & Argilés, J.M.
Amino acid metabolism enzyme activities in the obese Zucker rat.
Cellular and Molecular Biology  39: 405-414 (1993). (A)


86) García-Martínez, C., Agell, N., Llovera, M., López-Soriano, F.J. & Argilés, J.M.
Tumour necrosis factor-a increases the ubiquitinization of rat skeletal muscle proteins.
  FEBS Letters  323: 211-214 (1993). (A)


87) López-Soriano, J., Argilés, J.M. & López-Soriano, F.J.
Effects of tumour necrosis factor-a on enzymatic activities related to glucose metabolism.
Biochemistry and Molecular Biology International  30: 21-27 (1993). (A)


88) Llovera, M., López-Soriano, F.J. & Argilés, J.M.
Chronic tumour necrosis factor-a treatment modifies protein turnover in rat tissues.
Biochemistry and Molecular Biology International  30: 29-36 (1993). (A)


89) Fernández-López, J.A., Casado, J., Esteve, M., Rafecas, I., Argilés, J.M., Remesar, X. & Alemany, M.
Intestinal and hepatic nitrogen balance in the rat after the administration of an oral protein load.
British Journal of Nutrition  69: 733-742 (1993). (A)


90) Arbós, J., Zegrí, A., López-Soriano, F.J.. & Argilés, J.M. 
A simple method for determining the rate of gastrointestinal transit in the rat.
Archives Internationales de Physiologie et Biochimie  101: 113-115 (1993). (A)


91) García-Martínez, C., Llovera, M., López-Soriano, F.J. & Argilés, J.M.
The effects of endotoxin administration on blood amino acid concentrations: similarities with sepsis.
Cellular and Molecular Biology  39: 537-542 (1993). (A)


92) Llovera, M., López-Soriano, F.J. & Argilés, J.M
Effects of tumour necrosis factor-a on muscle-protein turnover in vivo in female Wistar rats.
Journal of the National Cancer Institute  85: 1334-1339 (1993). (A)


93) García-Martínez, C., López-Soriano, F.J. & Argilés, J.M.
Acute treatment with tumour necrosis factor-a induces changes in protein metabolism in rat skeletal muscle.
  Molecular and Cellular Biochemistry  125: 11-18 (1993). (A)

94) Llovera, M., López-Soriano, F.J. & Argilés, J.M.
Tumour necrosis factor-a alters the blood compartmentation of amino acids in the rat.
Cancer Letters  72: 71-76 (1993). (A)


95) Domènech, M., López-Soriano, F.J. & Argilés, J.M.
Alanine as a lipogenic precursor in isolated hepatocytes from obese Zucker rats.
Cellular and Molecular Biology  39: 693-699 (1993). (A)


96) Marzábal, M., García-Martínez, C., Comas, J., López-Soriano, F.J. & Argilés, J.M.
A flow cytometric study of the rat Yoshida AH-130 ascites hepatoma.
  Cancer Letters  72: 169-173 (1993). (A)


97) Costelli, P., Carbó, N., Tessitore, L., Bagby, G.J., López-Soriano, F.J., Argilés, J.M. &7Baccino, F.M.
Tumour necrosis factor-a mediates changes in tissue protein turnover in a rat cancer cachexia model.
Journal of Clinical Investigation  92: 2783-2789 (1993). (A)


98) García-Martínez, C., López-Soriano, F.J. & Argilés, J.M.
Interleukin-6 does not activate protein breakdown in rat skeletal muscle.
Cancer Letters  76: 1-4 (1994). (A)

99) Llovera, M., García-Martínez, C., Agell, N., Marzábal, M., López-Soriano, F.J. & Argilés, J.M.
Ubiquitin gene expression is increased in skeletal muscle of tumour-bearing rats.
FEBS Letters  338: 311-318 (1994). (A)


100) García-Martínez, C., Llovera, M., Agell, N., López-Soriano, F.J. & Argilés, J.M.
Ubiquitin gene expression in skeletal muscle is increased by tumour necrosis factor-a.
Biochemical Biophysical Research Communications  201: 682-686 (1994). (A)


101) Carbó, N., López-Soriano, F.J. & Argilés, J.M.
The effects of tumour necrosis factor-a on circulating amino acids in the pregnant rat.
Cancer Letters  79: 27-32 (1994). (A)


102) Argilés, J.M., López-Soriano, J. & López-Soriano, F.J.
The role of cytokines in diabetes: update 1994.
Endocrine Reviews Monographs  2: 76-80 (1994). (R)


103) Carbó, N., Costelli, P., Tessitore, L., Bagby, G.J., López-Soriano, F.J., Baccino, F.M. & Argilés, J.M.
Anti-tumour necrosis factor-a treatment interferes with changes in lipid metabolism in a tumour cachexia model.
Clinical Science  87: 349-355 (1994). (A)


104) Llovera, M., García-Martínez, C., López-Soriano, F.J. & Argilés, J.M.
The effect of chronic tumor necrosis factor-a administration on urinary nitrogen excretion in the rat.
Biochemistry and Molecular Biology International  33: 681-689 (1994). (A)


105) Argilés, J.M., López-Soriano, J. & López-Soriano, F.J.
Cytokines and diabetes: the final step? Involvement of TNF-a in both type I and II diabetes mellitus.
Hormone and Metabolic Research  26: 447-449 (1994). (A)


106) García-Martínez, C., López-Soriano, F.J. & Argilés, J.M.
Alanine metabolism in rats bearing the Yoshida AH-130 ascites hepatoma.
Cancer Letters  87: 123-130 (1994). (A)


107) Argilés, J.M.
"Cocina y salud".
Ediciones Martínez Roca, Barcelona (1994). (L)
ISBN 84-270-1907-6.


108) Carbó, N., López-Soriano, F.J. & Argilés, J.M.
The effects of tumour growth on circulating amino acids in the late pregnant rat.
Cancer Letters  88: 21-25 (1995). (A)


109) López-Soriano, J., Argilés, J.M. & López-Soriano, F.J.
Marked hyperlipidaemia in rats bearing the Yoshida AH-130 ascites hepatoma.
Biochemical Society Transactions  23: 492S (1995). (A)


110) López-Soriano, J., Argilés, J.M. & López-Soriano, F.J.
Metabolic effects of tumour necrosis factor-a on rat brown adipose tissue.
Molecular and Cellular Biochemistry  143: 113-118 (1995). (A)


111) Llovera, M., García-Martínez, C., Agell, N., López-Soriano, F.J. & Argilés, J.M.
Muscle wasting associated with cancer cachexia is linked to an important activation of the ATP-dependent ubiquitin-mediated proteolysis.
International Journal of Cancer  61: 138-141 (1995). (A)


112) Costelli, P., Llovera, M., García-Martínez, C., Carbó, N., López-Soriano, F.J. & Argilés, J.M.
Enhanced leucine oxidation in rats bearing an ascites hepatoma (Yoshida AH-130) and its reversal by clenbuterol.
Cancer Letters  91: 73-78 (1995). (A)


113) Costelli, P., García-Martínez, C., Llovera, M., Carbó, N., López-Soriano, F.J., Agell, N., Tessitore, L., Baccino, F.M. & Argilés, J.M.
Muscle protein waste in tumor-bearing rats is effectively antagonized by a b2-adrenergic agonist (clenbuterol
Journal of Clinical Investigation  95: 2367-2372 (1995). (A)


114) Carbó, N., López-Soriano, F.J. & Argilés, J.M
Administration of tumour necrosis factor-a results in a decreased placental transfer of amino acids in the rat.
Endocrinology  136: 3579-3584 (1995). (A)


115) García-Martínez, C., Llovera, M., López-Soriano, F.J., Del Santo, B. & Argilés, J.M.
Lipopolysaccharide (LPS) increases the in vivo oxidation of branched-chain amino acids in the rat: a cytokine-mediated effect.
Molecular and Cellular Biochemistry  148: 9-15 (1995). (A)


116) García-Martínez, C., López-Soriano, F.J. & Argilés, J.M.
Amino acid uptake in skeletal muscle of rats bearing the Yoshida AH-130 ascites hepatoma.
Molecular and Cellular Biochemistry  148: 17-23 (1995). (A)


117) Costelli, P., Llovera, M., Carbó, N., García-Martínez, C., López-Soriano, F.J. & Argilés, J.M.
Interleukin-1 receptor antagonist (IL-1ra) is unable to reverse cachexia in rats bearing an ascites hepatoma (Yoshida AH-130).
Cancer Letters  95: 33-38 (1995). (A)


118) Pallarés-Trujillo, J., López-Soriano, F.J. & Argilés, J.M.
TNF and AIDS: two sides of the same coin?
Medicinal Research Reviews  15: 533-546 (1995). (R)


119) Costelli, P., Llovera, M., López-Soriano, J., Carbó, N., Tessitore, L., López-Soriano, F.J., Baccino, F.M. & Argilés, J.M.
Lack of effect of eicosapentaenoic acid in preventing cancer cachexia and inhibiting tumour growth.
Cancer Letters  97: 25-32 (1995). (A)


120) Dessí, S., Batetta, B., Spano, O., Bagby, G.J., Tessitore, L., Costelli, P., Baccino, F.M., Pani, P. & Argilés, J.M.
Perturbations of triglycerides but not of cholesterol metabolism are prevented by anti-tumour necrosis factor treatment in rats bearing an ascites hepatoma (Yoshida AH-130)
British Journal of Cancer  72: 1138-1143 (1995). (A)


121) Llovera, M., García-Martínez, C., Costelli, P., Agell, N., Carbó, N., López-Soriano, F.J. & Argilés, J.M.
Muscle hypercatabolism during cancer cachexia is not reversed by the glucocorticoid receptor antagonist RU38486.
Cancer Letters  99: 7-14 (1996). (A)


122) García-Martínez, C. Llovera, M., Agell, N., López-Soriano, F.J. & Argilés, J.M.
Ubiquitin gene expression is increased in skeletal muscle is increased during sepsis: involvement of TNF-a but not IL-1.
Biochemical Biophysical Research Communications  217: 839-844 (1996). (A)


123) Carbó, N., López-Soriano, F.J., Fiers, W. & Argilés, J.M
Tumour growth results in changes in placental amino acid transport in the rat: a tumour necrosis factor a-mediated effect.
Biochemical Journal  313: 77-82 (1996). (A)


124) Llovera, M., Carbó, N., García-Martínez, C., Costelli, P., Tessitore, L., Baccino, F.M., Agell, N., Bagby, G.J., López-Soriano, F.J. & Argilés, J.M 
Anti-TNF treatment reverts increased muscle ubiquitin gene expression in tumour-bearing rats
Biochemical Biophysical Research Communications  221: 653-655 (1996). (A)


125) Argilés, J.M. & López-Soriano, F.J.
The ubiquitin-dependent proteolytic pathway in skeletal muscle: its role in pathological states.
Trends in Pharmacological Sciences  17: 223-226 (1996). (R)


126) Argilés, J.M., Costelli, P., Carbó, N. & López-Soriano, F.J.
Branched-chain amino acid metabolism and cancer cachexia.
Oncology Reports  3: 687-690 (1996). (R)


127) Carbó, N., López-Soriano, F.J. & Argilés, J.M
Tumour growth and fetal uptake of amino acids in the pregnant rat.
European Journal of Cancer  32A: 1413-1419 (1996). (A)


128) López-Soriano, J., Argilés, J.M. & López-Soriano, F.J.
Lipid metabolism in rats bearing the Yoshida AH-130 ascites hepatoma.
Molecular and Cellular Biochemistry  165: 17-23 (1996). (A)


129) López-Soriano, J., Carbó, N., Costelli, P., López-Soriano, F.J. & Argilés, J.M.
a-adrenergic receptors may contribute to the hypertriglyceridemia associated with tumour growth.
Cancer Letters  110: 213-216 (1996). (A)


130) Argilés, J.M., Carbó, N. & López-Soriano, F.J.
Metabolic alterations induced by tumour growth during the perinatal phase.
Ars Pharmaceutica  37: 907-920 (1996). (R)

131) Argilés, J.M. & López-Soriano, F.J.
Nutrición y cáncer: prevenir para no curar.
Tecnologia i Ciència dels Aliments  0: 15-32 (1997). (A)


132) García-Martínez, C., Costelli, P., López-Soriano, F.J. & Argilés, J.M.
Is TNF really involved in cachexia?
Cancer Investigation  15: 47-54 (1997). (R)


133) Llovera, M., García-Martínez, C., Agell, N., López-Soriano, F.J. & Argilés, J.M.
TNF can directly induce the expression of ubiquitin-dependent proteolytic system in rat soleus muscles.
Biochemical Biophysical Research Communications  230: 238-241 (1997). (A)


134) Argilés, J.M. & López-Soriano, F.J.
Cancer cachexia: a key role for TNF?
International Journal of Oncology  10: 565-572 (1997). (R)


135) Carbó, N., López-Soriano, F.J. & Argilés, J.M
Neutral amino acid transport in placental membrane vesicles in the late pregnant rat. Evidence for a B0-like transport system.
European Journal of Obstetrics & Gynecology and Reproductive Biology  71: 85-90 (1997). (A)


136) Pallarés-Trujillo, J., Agell, N., García-Martínez, C., López-Soriano, F.J. & Argilés, J.M.
The ubiquitin system, a role in disease?
Medicinal Research Reviews  17: 139-161 (1997). (R)


137) Carbó, N., López-Soriano, J., Tarragó, T, González, O., Llovera, M., López-Soriano, F.J. & Argilés, J.M.
Comparative effects of b2-agonists on muscle waste associated with tumour growth.
Cancer Letters  115: 113-118 (1997). (A)


138) López-Soriano, J., López-Soriano, F.J., Bagby, G., Williamson D.H. & Argilés, J.M.
Anti-TNF treatment does not reverse the abnormalities in lipid metabolism of the obese Zucker rat.
American Journal of Physiology  272: E656-E660 (1997). (A)


139) Argilés, J.M. & López-Soriano, F.J. 
Interrelaciones metabólicas entre el huésped y el tumor durante la fase perinatal.
Medicina Clínica  109: 186-194 (1997). (A)


140) López-Soriano, J., Argilés, J.M. & López-Soriano, F.J.
Sequential changes in lipoprotein lipase activity and lipaemia induced by the Yoshida AH-130 ascites hepatoma in rats.
Cancer Letters  116: 159-165 (1997). (A)


141) Rodríguez, T., Alvarez, B., Busquets, S., Carbó, N., López-Soriano, F.J. & Argilés, J.M.
The increased skeletal muscle protein turnover of the streptozotozin diabetic rat is associated with high concentrations of branched-chain amino acids.
Biochemical and Molecular Medicine  61: 87-94 (1997). (A)


142) Argilés, J.M., López-Soriano, J., Busquets, S. & López-Soriano, F.J.
Journey from cachexia to obesity by TNF.
FASEB Journal  11: 743-751 (1997). (A)


143) Argilés, J.M., Alvarez, B. & López-Soriano, F.J.
The metabolic basis of cancer cachexia.
Medicinal Research Reviews  17: 477-498 (1997). (R)


144) López-Soriano, J, Llovera, M., Carbó, N., García-Martínez-C., López-Soriano, F.J. & Argilés, J.M.
Lipid metabolism in tumour-bearing mice. Studies with knockout mice for tumour necrosis factor receptor-1 protein.
Molecular and Cellular Endocrinology  132: 93-99 (1997). (A)


145) Hulstijn, M., López-Soriano, J., López-Soriano, F.J. & Argilés, J.M.
Lipogenesis in rat tissues following carbohydrate refeeding. Spleen lipogenesis is modulated by insulin.
Molecular and Cellular Biochemistry  175: 149-152 (1997). (A)


146) Argilés, J.M., Carbó, N. & López-Soriano, F.J.
TNF and pregnancy: the paradigm of a complex interaction.
Cytokine and Growth Factors Reviews  8: 181-188 (1997). (R)


147) Carbó, N., Costelli, P., López-Soriano, F.J. & Argilés, J.M.
Tumour growth influences skeletal muscle protein turnover in the pregnant rat.
Pediatric Research  43: 250-255 (1998). (A)


148) Argilés, J.M., Carbó, N., Costelli, P. & López-Soriano, F.J.
Prevention of cancer and cardiovascular diseases: a common strategy?
Medicinal Research Reviews  18: 139-148 (1998). (R)


149) Argilés, J.M. & López-Soriano, F.J.
Catabolic proinflammatory cytokines.
Current Opinion in Clinical Nutrition and Metabolic Care  1: 245-251 (1998). (R)


150) Carbó, N., López-Soriano, F.J. & Argilés, J.M.
Was tumour necrosis factor-a responsible for the fetal malformations associated with thalidomide in the early 1960s? 
Medical Hypotheses  50: 313-318 (1998). (A)


151) Rodríguez, T., Busquets, S., Alvarez, B., Carbó, N., Agell, N, López-Soriano, F.J. & Argilés, J.M.
Protein turnover in skeletal muscle of the diabetic rat: activation of ubiquitin-dependent proteolysis.
International Journal of Molecular Medicine  1: 971-977 (1998). (A)


152) Argilés, J.M. & López-Soriano, F.J.
El resveratrol, ¿una molécula mágica?
Mundo Científico  18: 38-41 (1998). (A)


153) Pallarés-Trujillo, J., López-Soriano, F.J. & Argilés, J.M.
The involvement of the ubiquitin system in Alzheimer's disease.
International Journal of Molecular Medicine  2: 3-15 (1998). (A)


154) Llovera, M., García-Martínez, C., Agell, N., López-Soriano, F.J., Authier, F.J., Gherardi, R.K. & Argilés, J.M.
Ubiquitin and proteasome gene expression is increased in skeletal muscle of slim AIDS patients.
International Journal of Molecular Medicine  2: 69-73 (1998). (A)


155) Carbó, N., López-Soriano, F.J. & Argilés, J.M.
Tumour necrosis factor-a does not cross the rat placenta.
Cancer Letters  128: 101-104 (1998). (A)


156) Llovera, M., Carbó, N., López-Soriano, J., García-Martínez-C., Agell, N., López-Soriano, F.J., García, I. & Argilés, J.M.
Protein turnover in skeletal muscle of tumour-bearing transgenic mice overexpressing the soluble TNF receptor-1.
Cancer Letters  130: 19-27 (1998). (A)


157) López-Soriano, J, Carbó, N., López-Soriano, F.J. & Argilés, J.M.
Short-term effects of leptin on lipid metabolism in the rat.
FEBS Letters  431: 371-374 (1998). (A)


158) Argilés, J.M. & López-Soriano, F.J.
Host metabolism: a target in clinical oncology?
Medical Hypotheses  51: 411-415 (1998). (A)


159) Argilés, J.M. & López-Soriano, F.J.
El cáncer y su prevención.  La importancia de la alimentación.  
Ediciones de la Universidad de Barcelona,Colección Omnia 1998 (L)
ISBN 84-8338-037-4


160) Llovera, M., Carbó, N., López-Soriano, J., García-Martínez, C., Carbó, N., Agell, N., López-Soriano, F.J. & Argilés, J.M.
Role of TNF receptor 1 in protein turnover during cancer cachexia using gene knockout mice.
Molecular and Cellular Endocrinology  142: 183-189 (1998). (A)


161) Sanchís, D., Busquets, S., Alvarez, B., Ricquier, D., López-Soriano, F.J. & Argilés, J.M.
Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model.
FEBS Letters  436: 415-418 (1998). (A)


162) López-Soriano, F.J., Carbó, N., López-Soriano, J. & Argilés, J.M.
Leptin levels and gene expression during the perinatal phase in the rat.
European Journal of Obstetrics & Gynecology and Reproductive Biology  81: 95-100 (1998). (A)


163) Argilés, J.M., Pallarés-Trujillo, J. & López-Soriano, F.J.
Papel del sistema de la ubiquitina en la etiología del cáncer y otras enfermedades.
Medicina Clínica  119: 423-426 (1998). (A)


164) Busquets, S., Sanchís, D., Alvarez, B., Ricquier, D., López-Soriano, F.J. & Argilés, J.M.
In the rat, tumor necrosis factor aadministration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: a possible mechanism for cytokine-induced thermogenesis?
FEBS Letters  440: 348-350 (1998). (A)


165) Argilés, J.M., López-Soriano, F.J. & Pallarés-Trujillo, J.
"Ubiquitin and Disease".
R.G. Landes Publishing Company, Austin, Texas, USA, 174 pp. (1998).
ISBN 1-57059-545-3. (L)


166) Llovera, M., Carbó. N., López-Soriano, J., García-Martínez, C., Busquets, S., Alvarez, B., Agell, N., Costelli, P., López-Soriano, F.J., Celada, A. & Argiles, J.M. 
Different cytokines modulate ubiquitin gene expression in rat skeletal muscle. 
Cancer Letters  133: 83-87 (1998). (A)


167) Argiles, J.M., García-Martínez, C., Llovera, M. & López-Soriano, F.J.
The role of tumor necrosis factor-a in muscle wasting disorders.
Basic and Applied Myology  8: 371-380 (1998). (R)


168) Pallarés-Trujillo, J., López-Soriano, F.J. & Argilés, J.M.
The ubiquitin-dependent proteolysis and Alzheimer´s disease: a role in brain repair.
Alzheimer Actualities  140: 6-11 (1999). (R)


169) Argilés, J.M. Costelli, P., Carbó, N., Pallarés-Trujillo, J. & López-Soriano, F.J.
Tumour growth and nitrogen metabolism in the host.
International Journal of Oncology  14: 479-486 (1999). (A) 


170) Carbó, N., Costelli, P., Baccino, F.M., López-Soriano, F.J. & Argilés, J.M.
Resveratrol, a natural compound present in wine, decreases tumour growth in a rat tumour model.
Biochemical Biophysical Research Communications  254: 739-743 (1999). (A)


171) Llovera, M., García-Martínez, C., Agell, N., López-Soriano, F.J., Authier, F.J., Gherardi, R.K. & Argilés, J.M.
Ubiquitin gene expression is increased in human muscle undergoing neurogenic involvement.
Neurochemistry International  34: 137-140 (1999). (A)


172) Argilés, J.M., Busquets, S., Alvarez, B. & López-Soriano, F.J.
Mechanism for the increased skeletal muscle protein degradation in the obese Zucker rat.
Journal of Nutritional Biochemistry  10: 244-248 (1999). (A)


173) López-Soriano, J., Carbó, N., Tessitore, L., López-Soriano, F.J. & Argilés, J.M.
Leptin and tumour growth in rats.
International Journal of Cancer  81: 726-729 (1999). (A)


174) Argilés, J.M. & López-Soriano, F.J.
The role of cytokines in cancer cachexia.
Medicinal Research Reviews  19: 223-248 (1999). (R)


175) Bulló-Bonet, M., García-Lorda, P., López-Soriano, F.J., Argilés, J.M. & Salas-Salvado, J.
TNF, a key role in obesity?
FEBS Letters  451: 215-219 (1999). (R)


176) López-Soriano, F.J., López-Soriano, J., Carbó, N. & Argilés, J.M.
Leptin administration to lactating rats is unable to induce changes in lipid metabolism in white adipose tissue or mammary gland.
European Journal of Obstetrics & Gynecology and Reproductive Biology  84: 93-97 (1999). (A)


177) Argilés, J.M., Carbó, N. & López-Soriano, F.J.
Mecanismes moleculars associats a la caquèxia cancerosa.
"Patología Molecular" (editor: R. Bartrons). Societat Catalana de Biologia, vol. 49, pp. 53-70 (1999). (CL)


178) Argilés, J.M., Ribas, V. & López-Soriano, F.J.
TNF-alpha and reproduction: good or bad?
Rivista di Immunologia ed Immunofarmacologia  19: 43-47 (1999). (R)


179) Pallarés-Trujillo, J., López-Soriano, F.J. & Argilés, J.M.
Lipids: a key role in multidrug resistance?
International Journal of Oncology  16: 783-798 (2000). (R)


180) Van Royen, M., Carbó, N., Busquets, S., Alvarez, N., Quinn, L.S., López-Soriano, F.J. & Argilés, J.M. 
DNA fragmentation occurs in skeletal muscle during tumour growth: a link with cancer cachexia?
Biochemical Biophysical Research Communications  270: 533-537 (2000). (A)


181) Pallarés-Trujillo, J., Carbó, N., López-Soriano, F.J. & Argilés, J.M.
Does the mechanism responsible for TNF-mediated insulin-resistance involve the proteasome?
Medical Hypotheses  54: 565-569 (2000). (A)


182) Bulló-Bonet, M., García-Lorda, P., Argilés, J.M. & Salas-Salvado, J.
Papel del factor de necrosis tumoral en el control de las reservas grasas y la obesidad.
Medicina Clínica  114: 624-630 (2000). (R)


183) Xaus, J., Comalada, M., Valledor, A.F, Lloberas, J., López-Soriano, F.J., Argilés, J.M., Bogdan, C. & Celada, A.
LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-a
Blood  95: 3823-3831 (2000). (A)


184) Busquets, S., García-Martínez, C., Alvarez, B., Carbó, N., López-Soriano, F.J. & Argilés, J.M. 
Calpain-3 gene expression is decreased during experimental cancer cachexia.
Biochimica et Biophysica Acta  1475: 5-9 (2000). (A)


185) Carbó, N., López-Soriano, J., Costelli, P., Busquets, S., Alvarez, B., Baccino, F.M., Quinn, L.S., López-Soriano, F.J. & Argilés, J.M.
Interleukin 15 antagonizes muscle protein waste in tumor-bearing rats.
British Journal of Cancer  83: 526-531 (2000). (A)


186) Tessitore, L., Vizio, B., Jenkins, O., De Stefano, I., Ritossa, C., Argilés, J.M., Benedetto, C. & Mussa, A.
Leptin expression in colorectal and breast cancer patients.
International Journal of Molecular Medicine  5: 421-426 (2000). (A)


187) Busquets, S., Alvarez, B., Llovera, M., Agell, N., López-Soriano, F.J. & Argilés, J.M.
Branched-chain amino acids inhibit proteolysis in rat skeletal muscle: mechanisms involved.
Journal of Cellular Physiology  184: 380-384 (2000). (A)


188) Busquets, S., Alvarez, B., van Royen, M., Carbó, N., López-Soriano, F.J. & Argilés, J.M. 
Lack of effect of the cytokine suppresive agent FR167653 on tumour growth and cachexia in rats bearing the Yoshida AH-130 ascites hepatoma.
Cancer Letters  157: 99-103 (2000). (A)


189) Argilés, J.M. & López-Soriano, F.J. 
New mediators in cancer cachexia.
"Cancer and Nutrition: Prevention and Treatment" (editores: J.B. Mason & G. Nitenberg) Nestlé Nutrition Workshop Series, vol. 4, pp. 147-165, S. Karger AG, Basel (2000). (CL)


190) Carbó, N., Ribas, V., Busquets, S., Alvarez, B., López-Soriano, F.J & Argilés, J.M.
Short-term effects on leptin on skeletal muscle protein metabolism in the rat.
Journal of Nutritional Biochemistry  11: 431-435 (2000). (A)


191) Argilés, J.M., Alvarez, B., Carbó, N., Busquets, S., van Royen, M. & López-Soriano, F.J.
The divergent effects of tumour necrosis factor-alpha on skeletal muscle: implications in wasting.
European Cytokine Network  11: 552-559 (2000). (R)


192) Argilés, J.M., Meijsing, B., Pallarés-Trujillo, J., Guirao, X. & López-Soriano, F.J.
Cancer cachexia: a therapeutic approach.
Medicinal Research Reviews  21: 83-101 (2001). (R)


193) Busquets, S., Alvarez, B., van Royen, M., Figueras, M.T., López-Soriano, F.J. & Argilés, J.M. 
Increased uncoupling protein-2 gene expression in brain of lipopolysaccharide-injected mice: role of tumour necrosis factor-a?
Biochimica et Biophysica Acta  1499: 249-256 (2001). (A)


194) Argilés, J.M. & López-Soriano, F.J.
Insulin and cancer.
International Journal of Oncology  18: 683-687 (2001). (A)


195) Bink, H., Carbó, N., Felipe, A., López-Soriano, F.J. & Argilés, J.M.
Hepatic transport of gluconeogenic substrates during tumor growth in the rat.
Cancer Investigation  19: 248-255 (2001). (A)


195) Carbó, N., López-Soriano, J., Costelli, P., Alvarez, B., Busquets, S., Baccino, F.M., Quinn, L.S., López-Soriano, F.J., & Argilés, J.M
Interleukin-15 mediates reciprocal regulation of adipose tissue and muscle mass: a potential role in body weight control.
Biochimica et Biophysica Acta  1526: 17-24 (2001). (A)


197) Busquets, S., Carbó, N., Almendro, V., Quiles, M.T., López-Soriano, F.J. & Argilés, J.M.
Curcumin, a natural product present in turmeric, decreases tumor growth but it does not behave as an anticachectic compund in a rat model. 
Cancer Letters  167: 33-38 (2001). (A)


198) Bossola, M., Muscaritoli, M., Costelli, P., Bellantone, R,, Pacelli, F., Busquets, S., Argilés, J.M., López-Soriano, F.J, Civello, I.M., Baccino, M., Rossi-Fanelli, P., Doglietto, G.B.
Increased muscle ubiquitin mRNA levels are increased in gastric cancer patients.
American Journal of Physiology  280: R1518-R1523 (2001). (A) 


199) Argilés, J.M , Busquets, S., López-Soriano, F.J.
Metabolic interrelatioships between liver and skeletal muscle in pathological states.
Life Sciences  69: 1345-1361 (2001). (R)

200) Alvarez, B., Quinn, L.S., Busquets, S, López-Soriano, F.J. & Argilés, J.M. 
Direct effects of tumour necrosis factor-a (TNF-a on murine skeletal muscle cell lines. Bimodal effects on protein metabolism.
European Cytokine Network  12: 399-410 (2001). (A)

201) Busquets, S., Carbó, N., Almendro, V., Figueras, M.T., López-Soriano, F.J. & Argilés, J.M.
Hyperlipemia: a role in regulating UCP3 gene expression in skeletal muscle during cancer cachexia?
FEBS Letters  505: 255-258 (2001). (A)


202) Argilés, J.M. 
Alimentos anti-cancer.
Saber Vivir  19: 46-50 (2001) (A)


203) Rabinovich, R.A., Ardite, E., Troosters, T., Carbó, N., Alonso, J., González de Suso, J.M., Vilaró, J., Barberà, J.A., Argilés, J.M., Figueras-Polo, M., Fernández-Checa, C. & Roca, J.
Reduced muscle redox capacity after endurance training in patients with COPD.
American Journal of Respiratory and Critical Care Medicine  164: 1114-1118 (2001). (A)


204) Argilés, J.M. & López-Soriano, F.J.
El càncer: introducció.
"Càncer i Nutrició" (editores: J.M. Argilés & F.J. López-Soriano). Societat Catalana de Biologia, vol. 52, pp. 9-13 (2001). (CL)


205) Argilés, J.M. & López-Soriano, F.J.
Canvis metabòlics associats al càncer.
"Càncer i Nutrició" (editores: J.M. Argilés & F.J. López-Soriano). Societat Catalana de Biologia, vol. 52, pp. 67-82 (2001). (CL)


206) Argilés, J.M. & López-Soriano, F.J.
Anticarcinògens presents en aliments.
"Càncer i Nutrició" (editores: J.M. Argilés & F.J. López-Soriano). Societat Catalana de Biologia, vol. 52, pp. 109-122 (2001). (CL)


207) Argilés, J.M., Desccombes, P. & López-Soriano, F.J.
Les facteurs cataboliques du cancer: données récentes.
Nutrition Clinique et Métabolisme, 16: 14-25 (2002) (R)


208) Alvarez, B., Quinn, L.S., Busquets, S., López-Soriano, F.J. & Argilés, J.M.
TNF-a modulates cytokine and cytokine receptors in C2C12 myotubes.
Cancer Letters, 175: 181-185 (2002). (A)


209) Alvarez, B., Quinn, L.S., Busquets, S., Quiles, M.T., López-Soriano, F.J. & Argilés, J.M.
Tumor necrosis factor-a exerts interleukin-6-dependent and -independent effects on cultured skeletal muscle cells.
Biochimica et Biophysica Acta, 1570: 33-37 (2002). (A)


210) Argilés, J.M. & López-Soriano, F.J. 
Cancer cachexia.
"Skeletal Muscle: Pathology, Diagnosis and Management of Disease" (editores: V.R. Preedy & T.J. Peters), pp. 61-74, Gavin Smith Books  (2002). (CL)


211) Argilés, J.M., Alvarez, B. & López-Soriano, F.J.
Cultivos celulares en nutrición.
"Técnicas y Métodos de Investigación en Nutrición Humana" (editor: A. Mijan de la Torre).  pp. 99-112, Novartis Consumer Health (2002). (CL)

212) Argilés, J.M., Busquets, S. & López-Soriano, F.J.
Trastornos nutricionales: fisiopatología.
"Soporte Nutricional en el paciente Oncológico" (editores: A. Sastre Gallego & C. Gómez-Candela). Bristol-Myers Squibb (2002). (CL)


213) Alvarez, B., Carbó, N., López-Soriano, J., Drivdahl, R.H., Busquets, S., López-Soriano, F.J., Argilés, J.M. & Quinn, L.S.
Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissue.
Biochimica et Biophysica Acta,, 1570: 33-37 (2002). (A)


214) Carbó, N., Busquets, S., van Royen, M., Alvarez, B., López-Soriano, F.J. & Argilés, J.M.
TNF-a is involved in activating DNA fragmentation in skeletal muscle.
British Journal of Cancer, 86: 1012-1016 (2002) (A)


215) Busquets, S., Alvarez, B., López-Soriano, F.J. & Argilés, J.M. 
Branched-chain amino acids: a role in skeletal muscle proteolysis in catabolic states?
Journal of Cellular Physiology, 191: 283-289 (2002). (A) 


216) Bullo, M., García-Lorda, P., Peinado-Onsurbe, J., Hernández, M., Del Castillo, D., Argilés, J.M. Salas-Salvadó, J.,
TNF-a expression of subcutaneous adipose tissue in obese and morbid obese females: relationship to adipocyte LPL activity and leptin synthesis.
International Journal of Obesity and Related Metabolic Disorders, 26: 652-658 (2002). (A)


217) Argilés, J.M., Busquets, S. & López-Soriano, F.J.
The role of uncoupling proteins (UCPs) in pathophysiological states.
Biochemical and Biophysical Research Communications, 293: 1145-1152 (2002) (R)


218) Quinn, L.S., Anderson, B.G., Drivdahl, R., Alvarez, B. & Argilés, J.M.
Overexpression of interleukin-15 induces skeletal muscle hypertrophy in vitro: implications for treatment of muscle wasting disorders.
Experimental Cell  Research 280: 55-63  (2002). (A)


219) Meijsing, B., Carbó, N., López-Soriano, F.J. & Argilés, J.M. 
Effects of the PDE-IV inhibitor EMD 95832/3 on tumour growth and cachexia in rats bearing the Yoshida AH-130 ascites hepatoma.
Cancer Letters 188: 53-58  (2002). (A)


220) Bossola, M., Muscaritoli, M., Costelli, P.,  Nanni, G., Tazza, L., Panocchia, N., Busquets, S.., Argilés, J.M., López-Soriano, F.J., Grieco, G., Baccino, F.M., Rossi-Fanelli, F., Castagneto, M. & Luciani, G.
Muscle ubiquitin mRNA levels in patients with end-stage renal disease on maintainance hemodialysis.
Journal of Nephrology 15: 552-557  (2002) (A)


221) Argilés, J.M., Moore-Carrasco, R., Fuster, G. Busquets, S. & López-Soriano, F.J.
Cancer cachexia --the molecular mechanisms.
International Journal of Biochemistry and Cell Biology  35: 405-409 (2003). (A)


222) Coma, M., Vicente, R., Busquets, S., Carbó, N., Tamkun, M.M., López-Soriano, F.J., Argilés, J.M. & Felipe, A.
Impaired voltage-gated potassium channel expression in brain during experimental cancer cachexia.
FEBS Letters 536: 45-50 (2003). (A)


223) Rabinovich, R.A., Figueras, M., Ardite, E., Carbó, N., Troosters, T., Filella, X., Barberà, J.A., Fernández-Checa, C., Argilés, J.M. & Roca, J.
Increased TNFa plasma levels during moderate-intensity exercise in COPD patients.
European Respiratory Journal 21:789-794 (2003). (A)


224) Argilés, J.M., Busquets, S. & López-Soriano, F.J.
Cytokines in the pathogenesis of cancer cachexia
Current Opinion in Clinical Nutrition and Metabolic Care  6:401-406, (2003). (R)


225) Busquets, S., Aranda, X., Ribas-Carbó, M., Azcón-Bieto, J., López-Soriano, F.J. & Argilés, J.M.
Tumour necrosis factor-a uncouples respiration in isolated rat mitochondria.
Cytokine  22: 1-4 (2003). (A)


226) Costelli, P., Aoki, P., Carbó, N, López-Soriano, F.J.,  Bonelli, G., Argilés, J.M. & Baccino, F.M.
Mice lacking TNF-a and its receptors I and II are resistant to death and fulminant liver injury induced by agonistic anti-FAS antibody.
Cell Death and Differentiation 10: 997-1004 (2003). (A)


227) Argilés, J.M., Busquets, S. Moore-Carrasco, R. & López-Soriano, F.J.
Catabolic mediators as targets for cancer cachexia
Drug Discovery Today  8: 838-844 (2003). (R)


228) Costelli, P., Carbó, N., Busquets, S. López-Soriano, F.J., Baccino, F.M., & Argilés, J.M.
Reduced protein degradation rates and low expression of proteolytic systems support skeletal muscle hypertrophy in transgenic mice overexpressing the c-ski oncogene.
Cancer Letters 200: 153-160 (2003). (A)


229) Almendro, V., Carbó, N, Busquets, S. Figueras, M.T., Tessitore, L., López-Soriano, F.J. & Argilés, J.M.
Sepsis induces DNA fragmentation in rat skeletal muscle.
European Cytokine Network  14:256-259 (2003). (A)


230) Argilés, J.M.
Nuevo tratamiento nutricional para la pérdida de peso inducida por cáncer. Caquexia cancerosa
JANO/Opinión del Experto  4-7, en prensa (2003). (A)


231) Argilés, J.M., Almendro, V., Busquets, S. & López-Soriano, F.J.
The pharmacological treatment of cachexia.
Current Drug Targets  5: 265-277 (2004). (R)


232) López-Soriano, J, Carbó, N., Almendro, V., Figueras, M.T., Ribas, V., Busquets, S., López-Soriano, F.J. & Argilés, J.M.
Rat liver lipogenesis is modulated by interleukin-15 (IL-15).
International Journal of Molecular Medicine 13: 817-819  (2004). (A)
.
233) Tessitore, L., Vizio, B., Pesola, D., Cecchini, F., Mussa, A., Argilés, J.M. & Benedetto, C.
Adipocyte expression and circulating levels of leptin increase in both gynecologycal and breast cancer patients.
International Journal of Oncology 24: 1529-1535 (2004). (A)


234) Argilés, J.M., Busquets, S. & López-Soriano, F.J.
Mediadores químicos en la anorexia-caquexia.
"Astenia Tumoral" (editor: M. González-Barón),  pp. 57-78  (2004). 
Editorial Médica Panamericana ISBN: 84-7903-962-0 (CL)


235) Figueras, M.T. Busquets, S., Carbó, N., Barreiro, E., Almendro, V., Argilés, J.M. & López-Soriano, F.J. 
Interleukin-15 is able to supress the increased DNA fragmentation associated with muscle wasting in tumour-bearing rats
FEBS Letters 569: 201-206  (2004). (A)


236) Vicente, R., Coma, M., Busquets, S., Moore-Carrasco. R. López-Soriano, F.J., Argilés, J.M. & Felipe, A.
The systemic inflammatory response is involved in the regulation of K+ channel expression in brain via TNF-a dependent and-independent pathways
FEBS Letters  572: 189-194 (2004). (A)


237) Busquets, S., Figueras, M.T., Fuster, G., Almendro, V., Moore-Carrasco, R., Ametller, E., Argilés, J.M. & López-Soriano, F.J. 
Anticachectic effects of formoterol: a potential drug for the treatment of muscle wasting.
Cancer Research  64: 6725-6731 (2004). (A)


238) Argilés, J.M., López-Soriano, J., Almendro, V., Busquets, S. & López-Soriano, F.J.
Cross-talk between skeletal muscle and adipose tissue: a link with obesity?
Medicinal Research Reviews  25: 49-65 (2004). (R)


239) Carbó, N., López-Soriano, F.J. & Argilés, J.M.
Plasma from pregnant rats has anti-tumoural activity.
Oncology Reports 12: 885-887 (2004). (A)


240) Carbó, N., Costelli, P., Busquets, S., López-Soriano, J., López-Soriano, F.J., Baccino, F.M. & Argilés, J.M..
Effect of c-SKI overexpression on the development of cachexia in mice bearing the Lewis lung carcinoma.
International Journal of Molecular Medicine 14: 719-723 (2004). (A)


241) Argilés, J.M.
Eficacia del soporte nutricional en el paciente oncológico.
Nutrición Clínica y Dietética Hospitalaria 24  Suppl. 1: 9-12 (2004). (A)


242) Argilés, J.M.,  Busquets, S. Felipe, A. & López-Soriano, F.J. 
Molecular mechanisms involved in muscle wasting in cancer and ageing: cachexia versus sarcopenia.
International Journal of Biochemistry and Cell Biology 37:1084-1104 (2005). (R)


243) Busquets, S., Almendro, V., Figueras, M.T., López-Soriano, F.J. & Argilés, J.M.
Activation of UCPs gene expression in skeletal muscle can be independent on both circulating fatty acids and food intake. Involvement of ROS in a model of mouse cancer cachexia.
FEBS Letters  579: 717-722, (2005). (A)

244) Barreiro, E.. de la Puente, B., Busquets, S., López-Soriano, F.J.,  Gea, J. & Argilés, J.M.
Both oxidative and nitrosative stress are associated with muscle wasting in tumour-bearing rats.
FEBS Letters 579: 1642-1652, (2005). (A)


245) Argilés, J.M. 
Nutrición y cáncer: 100 conceptos clave.
Editorial Glosa, Barcelona (2005). (L)
ISBN: 84-7429-237-9


246) Argilés, J.M.,  Busquets, S. & López-Soriano, F.J. 
The pivotal role of cytokines in muscle wasting during cancer.
International Journal of Biochemistry and Cell Biology  37: 1609-1619 (2005). (R)


247) Costelli, P., Muscaritoli, M., Bossola, M., Carrasco-Moore, R., Crepaldi, S., Grieco, G., Autelli, R., Bonelli, G., Pacelli, F., López-Soriano, F.J., Argilés, J.M., Doglietto, G.B., Baccino, F.M. & Rossi Fanelli, F.
Skeletal muscle wasting in tumour-bearing rats is associated with MyoD down-regulation.
International Journal of Oncology  26: 1663-1668 (2005). (A)


248) Almendro, V., Carbó, N., Busquets, S., López-Soriano-J., Figueras, M.T., Ametller, E., Argilés, J.M. & López-Soriano, F.J.  
Interleukin-15 decreases intestinal lipid absorption.
International Journal of Molecular Medicine 15: 963-967 (2005). (A)


249)   Argilés, J.M., Busquets, S. & López-Soriano, F.J.
Alteraciones metabólicas durante el síndrome de la caquexia asociada al cáncer: mediadores.
Revista Española de Obesidad 3: 125-137 (2005). (R)


250) Dejong, C.H.C., Busquets, S., Moses, A.G.W., Schrauwen, P., Ross, J.A., Argilés, J.M. & Fearon, K.H.C.
Systemic inflammation correlates with increased expression of skeletal muscle ubiquitin but not uncoupling proteins in cancer cachexia.
Oncology Reports 14: 257-263 (2005). (A)


251) Figueras, M., Busquets, S., Carbó, N., Almendro, V., Argilés, J.M. & López-Soriano, F.J.  
Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue.
International Journal of Oncology 27: 855-860 (2005). (A)


252) Quinn, L.S., Strait-Bodey, L. Anderson, B.G, Argilés, J.M. & Havel, P.J:
Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathway.
Cell Biology International 29: 449-457 (2005). (A)


253) Busquets, S., Figueras, M.T., Meijsing, S., Carbó, N., Quinn, L.S., Almendro, V., Argilés, J.M.  & López-Soriano, F.J.
Interleukin-15 decreases proteolysis in skeletal muscles: a direct effect.
International Journal of Molecular Medicine 16: 471-476 (2005). (A)


254) Argilés, J.M.,  Busquets, S. & López-Soriano, F.J. 
The pivotal role of cytokines in muscle wasting during cancer.
International Journal of Biochemistry and Cell Biology 37: 1609-1619 (2005). (R)


255) Argilés, J.M.
Cancer-associated malnutrition
European Journal of  Oncology Nursing  6: S39-S50 (2005). (R)


256)   Argilés, J.M., Busquets, S., García-Martínez, C. & López-Soriano, F.J.
Mediators involved in the cancer anorexia-cachexia syndrome: past, present and future
Nutrition  21: 977-985 (2005). (R)


257) Argilés, J.M.,  Busquets, S. & López-Soriano, F.J. 
Cytokines as mediators and targets for cancer cachexia.
“The link between inflammation and cancer" (editores: A. Dalgleish & B. Haefner). 
ISBN: 0-387-26282-2
Springer Publishers, Chapter 9 pp.199-217  (2005). (CL)


258) Argilés, J.M., Busquets, S. & López-Soriano, F.J.
Perspectives in cancer cachexia: cytokines as therapeutic targets
Current Trends in Endocrinology 1: 69-79 (2005). (R)


259) Argilés, J.M.
Pérdida de peso/caquexia en el paciente oncológico: causas y consecuencias.
Clinical and Translational Oncology  7 (suppl.) 3: 17-20  (2005). (R)


260) Argilés, J.M.,  Busquets, S. & López-Soriano, F.J. 
Mecanismos Fisiopatológicos.
Guía Clínica del Síndrome Anorexia-Caquexia (Ed. V. Valentin)
ISBN: 84-6096277-8
SEOM, Capítulo 3 pp. 47-60 (2005). (CL)


261) Moore-Carrasco. R., García-Martínez, C., Busquets, S., Ametller, E., Barreiro, E., López-Soriano, F.J. & Argilés, J.M.
The AP-1/cjun signaling cascade is involved in muscle differentiation : implications in muscle wasting during cancer cachexia.
FEBS Letters 580: 691-696 (2006). (A)


262)   Busquets, S., García-Martínez, C., Olivan, M., Barreiro, E., López-Soriano, F.J. & Argilés, J.M.
Overexpression of UCP3 in both murine and human myoblasts is linked with the activation of proteolytic systems: a role in muscle wasting?
Biochimica et Biophysica Acta 1760: 253-258 (2006). (A)


263) Almendro, V., Busquets, S., Ametller, E., Carbó, N., Figueras, M.T., Argilés, J.M. & Lopez-Soriano, F.J.
Effects of interleukin-15 (IL-15) on lipid oxidation.  Disposal of an oral [14C-triolein] load
Biochimica et Biophysica Acta 1761: 37-42 (2006). (A)


264) Argilés, J.M., Busquets, S., A. Felipe & López-Soriano, F.J.
Muscle wasting in cancer and ageing: cachexia versus sarcopenia.
Advances in Gerontology 18:39-54 (2006). (R)


265) López-Soriano, J. Chiellini, C., Maffei, M., Grimaldi, P.A. & Argilés, J.M.
Role of skeletal muscle and peroxisome proliferator-activated receptors in the development and treatment of obesity.
Endocrine Reviews 27: 318-329 (2006). (R)


266) Argilés, J.M., Busquets, S., López-Soriano, F.J. & Figueras, M.
Fisiopatología de la caquexia cancerosa.
Nutrición Hospitalaria 21 (suppl. 3); 4-9 (2006). (R)


267) Argilés, J.M., Busquets, S., López-Soriano, F.J. & Figueras, M.
Fisiología de la sarcopenia.  Similitudes y diferencias con la caquexia neoplásica.
Nutrición Hospitalaria 21 (suppl. 3); 38-45 (2006). (R)


268) Irminger-Finger, I., Busquets, S., Fabrice, C., López-Soriano, F.J. & Argilés, J.M.
Bard-1 content correlates with increased DNA fragmentation associated with muscle wasting in tumour-bearing animals
Oncology Reports 15: 1425-1428 (2006). (A)


269) Argilés, J.M. & Almendro, V., Busquets, S. & López-Soriano, F.J. 
Cancer cachexia and fat metabolism.
"Cachexia and Wasting" (editor: G. Mantovani). 
ISBN: 10 88-470-0471-3
Springer Publishers, Chapter 9 pp. 459-466   (2006). (CL)


270) Argilés, J.M.,  Busquets, S. Moore-Carrasco, R. & López-Soriano, F.J. 
The role of cytokines in cancer cachexia.
"Cachexia and Wasting" (editor: G. Mantovani) ISBN: 10 88-470-0471-3
Springer Publishers, Chapter 9 pp. 467-475   (2006). (CL)


271) Costelli, P., Muscaritoli, M., Bossola, M., Penna F.,  Reffo, P.,  Bonetto, A., Busquets, S., Bonelli, G., López-Soriano, F.J.,  Doglietto, G.B., Argilés, J.M., Baccino, F.M. & Rossi-Fanelli, F.
IGF-1 gene expression is down-regulated in experimental cancer cachexia
American Journal of Physiology 291: R674-83 (2006).  (A)


272) Busquets, S., Figueras, M.T., Almendro, V., Lopez-Soriano, F.J & Argilés, J.M.  .
Interleukin-15 increases glucose uptake in skeletal muscle. An antidiabetogenic effect of the cytokine.
Biochimica et Biophysica Acta 1760: 1613-1617 (2006). (A)


273) Palomo, I., Alarcon, M., Moore-Carrasco-R. & Argilés, J.M.  
Hemostasis alterations in the metabolic syndrome.
International Journal of Molecular Medicine 18: 969-974 (2006). (R)


274) Rabinovich, R.A., Ardite, E., Mayer, A.M., Figueras, M.T., Vilaró, J., Argilés, J.M. & Roca, J.
Training depletes muscle glutathione in COPD patients with loss body mass index.
Respiration 73: 757-761 (2006). (A)


275) Busquets, S., Ametller, E., Fuster, G., Olivan, M., Raab, V., Argilés, J.M. & Lopez-Soriano, F.J.
Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model.
Cancer Letters 245: 144-148 (2007). (A)


276) Argilés, J.M., Busquets, S., Moore-Carrasco, R., Figueras, M.T., Almendro, V. & López-Soriano, F.J.
Targets in clinical oncology: the metabolic environment of the patient.
Frontiers in Biosciences 12: 3024-3051 (2007). (R)


277) Busquets, S., Fuster, G., Ametller, E., Olivan, M., Figueras, M.T., Costelli, P., Carbó, N., Argilés, J.M. & Lopez-Soriano, F.J.
Resveratrol, does not ameliorate muscle wasting in different types of cancer cachexia models.
Clinical Nutrition  26: 239-244 (2007). (A)


278) Moore-Carrasco. R.,  Busquets, S., Almendro, V., Palanki, M., López-Soriano, F.J. & Argilés, J.M. 
The AP-1/NF-kB double inhibitor (SP100030) can revert muscle wasting during experimental cancer cachexia. 
International Journal of Oncology 30: 1239-1245  (2007). (A)


279) Costelli, P., Almendro, V., Figueras, M.T., Reffo, P., Penna, F., Aragno, M., Mastrocola, R., Boccuzzi, G., Busquets, S., Bonelli, G., Argilés, J.M. & Baccino, F.M.
Modulations of the calcineurin/ NF-AT pathway in skeletal muscle atrophy
Biochimica et Biophysica Acta 1770: 1028-1036  (2007). (A)


280) Fuster, G., Busquets, S., Ametller, E., Olivan, M., Almendro, V., Fontes de Oliveira, C.C., Figueras, M.T., Lopez-Soriano, F.J & Argilés, J.M.
   Are peroxisome proliferator-activated receptors involved in skeletal muscle during experimental cancer cachexia? Role of beta-2 adrenergic receptors.
Cancer Research 67:6512-6519  (2007). (A)


281) Vissers, Y.L.J., von Meyenfeldt, M., Argilés, J.M., Luiking, I.C., Dejong, C.H.C. & Deutz, N.E.P.
Protein breakdown on whole-body and organ level in non-cachectic umourbearing mice undergoing surgery.
Clinical Nutrition 26: 483-490 (2007). (A)


282) Fuster, G., Busquets, S.,  López-Soriano, F.J. & Argilés, J.M.  .
Antiproteolytic effects of plasma from hibernating bears: a new approach for muscle wasting therapy?
Clinical Nutrition 26. 658-661 (2007). (A)


283) Argilés, J.M., López-Soriano-F.J. & Busquets, S.
Emerging drugs for cancer cachexia.
Expert Opinion in Emerging Drugs 12: 555-570 (2007). (R)


284) Villalonga, N., Ferreres, J.C., Argilés, J.M., Condom, E. & Felipe, A.
Potassium channels are a new target field in anticancer drug design
Recent Patents on Anti-Cancer Drug Discovery 2: 212-223 (2007). (R)


285) Busquets, S., Dean, C., Figueras, M.T., Moore-Carrasco, R. López-Soriano, F.J., Fearon, K.H.C. & Argiles, J.M.
Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients.
Clinical Nutrition 26: 614-618 (2007). (A)


286) Argilés, J.M., López-Soriano-F.J. & Busquets, S.
Mechanisms to explain wasting of muscle and fat in cancer cachexia
Current Opinion in Supportive and Palliative Care 1: 293-298 (2007). (R)


287) Argilés, J.M., Figueras, M.T., Ametller, E., Fuster, G., Olivan, M., Fontes de Oliveira, C.C., López-Soriano-F.J., Isfort, R.J. & Busquets, S. 
Effects of CRF2R agonist on tumour growth and cachexia in mice implanted with Lewis lung carcinoma cells
Muscle and Nerve 37: 190-195 (2007). (A)


288) Moore-Carrasco. R., Figueras, M.T, Ametller, E., López-Soriano, F.J., Argilés, J.M. & Busquets, S.
Effects of the PPAR-gamma agonist GW1929 on muscle wasting in tumour-bearing mice
Oncology Reports 19: 253-256 (2008). (A)


289) Argilés, J.M., López-Soriano-F.J. & Busquets, S.
Novel Approaches for the treatment of cachexia.
Drug Discovery Today 13: 73-78 (2008). (R)


290) Almendro, V, Fuster, G., Busquets, S., Ametller, E. Figueras, M.T.,Argilés, J.M. & Lopez-Soriano, F.J.
Effects of interleukin-15 on rat brown adipose tissue: uncoupling proteins and peroxisome proliferator-activated receptors.
Obesity Research 16: 285-289 (2008).


291) Argilés, J.M., Busquets, S. & López-Soriano, F.J.
La dieta meditèrrania: una eina fonamental en la prevenció del càncer.
Omnis Cèl.lula 16: 10-15 (2008). (A)


292) Argilés, J.M., López-Soriano-F.J. & Busquets, S.
Apoptosis is essential and precedes protein degradation in wasting skeletal muscle during catabolic conditions
International Journal of Biochemistry and Cell Biology 40: 1674-1678 (2008). (A)


293) Evans, W.J., Morley, J.E., Argilés, J.M., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-Zadeh, K., Lochs, H., Mantovani, G., Marks, D., Mitch, W.E., Muscaritoli, M., Najand, A., Ponikowski, P., Rossi Fanelli, F., Schambelan, M., Schols, A., Schulster, M., Thomas, D., Wolfe, R. & Anker, S.D.
Cachexia and wasting disease: a new definition.
Clinical Nutrition 27: 793-799 (2008). (A)


294) Faber, J., Vos, P., Kegler, D., Van Norren,  K., Argilés, J.M., Laviano, A. Garssen, J. & van Helvoort, A.
Benefitial immune modulatory effects of a specific nutritional combination in a murine model for cancer cachexia.
British Journal of Cancer 99: 2029-2036 (2008).  (A)


295) Argilés, J.M., López-Soriano, F.J. & Busquets, S.
Therapeutic potential of interleukin-15: a myokine involved.
in muscle wasting and adiposity
Drug Discovery Today 14: 208-213 (2008). (A)


296) Moore-Carrasco. R.,  Aranguez-Arellano, C., Razmilic, I., Toloza, L., Morales, E., Argilés, J.M. & Palomo, I.
A high fat diet in CF-1 mice: an experimental model for metabolic syndrome.
Molecular Medicine Reports 1: 401-405 (2008). (A)


297) Quinn, L.S., Anderson, B., Strait-Bodey, L. & Argilés, J.M.
Oversecretion of interleukin-15 from skeletal muscle reduces adiposity.
American Journal of Physiology 296: E191-202 (2009).  (A)


298) Barreiro, E., Garcia-Martínez, C.,  Mas, S., Ametller, E., Argilés, J.M., Busquets, S. & López-Soriano, F.J.
UCP3 overepression neutralizes oxidative stress rather than nitrosative stress in mouse myotubes.
FEBS Letters 583: 350-356  (2009). (A)


299) Van Norren, K., van Helvoort, A., Argilés, J.M., van Tuijl, S., Karin, A., Gorselink, M, Laviano, A., Kegler, D., Haagsman, H.P. & van der Beek, E.M.
Direct effects of doxirubicin on skeletal muscle contribute to fatigue.
British Journal of Cancer 100: 311-314 (2009). (A)


300) Van Norren K., Kegler, D., Argilés, J.M., Luiking, Y., Gorselink, M., Laviano, A., Arks, K., Faber, J., Jansen, H.. van der Beek, E.M. & van Helvoort, A.
Dietary supplementation with a specific combination of high protein, leucine and fish oil improves muscle function and daily activity in tumor-bearing cachectic mice.
British Journal of Cancer 100: 713-722  (2009). (A)


301) Moore-Carrasco. R.,  Busquets, S., Palanki, M.,  López-Soriano, F.J. & Argilés, J.M.
Both AP-1 and NF-kB seem to be involved in tumour growth in an experimental rat hepatoma.
Anticancer Research 29: 1315-1317 (2009). (A)


302) Argilés, J.M., Busquets, S. & López-Soriano, F.J.
Fisiopatología de la caquexia asociada al cáncer
In “Actualizaciones en el metabolismo y la nutrición de órganos y sistemas” (Mercé Planas Vilà Ed.) Ediciones Aula Médica pp. 3-10 ISBN: 978-84-7885-486-8, (2009)  (CL)


303) Argilés, J.M., Busquets, S., & López-Soriano, F.J. 
Sarcopenia y caquexia neoplásica: similitudes y diferencias
In “Actualizaciones en el metabolismo y la nutrición de órganos y sistemas” (Mercé Planas Vilà Ed.)  Ediciones Aula Médica pp. 43-52  ISBN: 978-84-7885-486-8 (2009)  (CL)


304) Fuster, G., Busquets, S., Figueras, M.T., Ametller, E.,  Fontes de Oliveira, C.C., Olivan, M., Grimaldi, P.A.,  Argilés, J.M.  & López-Soriano, F.J.
PPAR-delta mediates IL-15 metabolic actions in myotubes: effects of hyperthermia 
International Journal of Molecular Medicine 24: 63-68 (2009) (A)


305) Almendro, V., Ametller, E., Costelli, P., Pilla, F., Fuster, G., Busquets, S., Figueras, M., Argilés, J.M. & López-Soriano, F.J.
Interleukin-15  increases calcineurin expression in 3T3-L1 cells: possible involment on in vivo adipocyte differentiation
International Journal of Molecular Medicine 24: 453-458 (2009) (A)


306) Faber, J., Vos, A.P., Refler, D., Argilés, J.M., Laviano, A., Garssen, J. & van Helvoort, A.
Impaired immune function. An early marker for cancer cachexia.
Oncology Reports 22: 1403-1406 (2009) (A)


307) Argilés, J.M., Busquets, S. & López-Soriano, F.J.
The role of uncoupling proteins in pathophysiological states
In “Muscle Plasticity-Advances in Physiological and Physiological Research” José Magalhaes and Antonio Ascensao Ed.  pp 195-207 ISBN: 978-81-308-0322-7 (2009) (CL)


308) Argilés, J.M., López-Soriano, F.J. Toledo, M. &   Busquets, S.
The role of cytokines in cancer cachexia.
Current Opinion in Supportive and Palliative Care  3: 263-268 (2009) (R)


309) Argilés, J.M., López-Soriano, F.J. & Busquets, S.
Cancer cachexia
In: “Encyclopedia of molecular mechanisms of disease”, pp. 266-268, ISBN: 978-3-54067136-7 (Florian Lang Ed), Springer, 2009  (CL)


310) Argilés, J.M., López-Soriano, F.J. Sirisi, S. &   Busquets, S.
Therapeutic strategies in cachexia: current and future directions.
Drugs of the Future 35: 41-52 (2010) (R)


311) Marín-Corral-J., Pascual-Guardia-S., Sánchez, F., Argilés, J.M., Busquets, S., López-Soriano-F.J & Barreiro, E.
Redox balance and carbonilated proteins in limb muscles and heart of cachectic rats.
Antioxidants and Redox Signaling 12: 365-380 (2010) (A)


312) Argilés, J.M., Anker, S.D., Evans, W.J., Morley, J., Fearon, K.C.H, Strasser, F., Muscaritoli, M. and Baracos V.
Consensus on cachexia definitions.
Journal of the American Medical Directors Association 11: 229-230 (2010) (A)


313) Muscaritoli, M., Anker, S.D., Argilés, J.M., Aversa, Z., Buer, J.M., Biolo, G., Boirie, Y., Cederholm, T., Fearon, K.C., Laviano. A., Schneider, A., Schols, A. & Sieber, C.C.
Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics".
Clinical Nutrition, 29:154-159 (2010) (A)


314) Argilés, J.M., Oliván, M., Busquets, S. & López-Soriano, F.J.
Optimal management of cancer anorexia-cachexia syndrome.
Cancer Management and Research 2: 27-38 (2010) (R)


315) Argilés, J.M., Busquets, S., Urpi, M.  &  López-Soriano, F.J.
Molecular mechanisms of muscle wasting in cancer and ageing: cachexia versus sarcopenia..
In “Advances in Experimental Medicine and Biology” Gordon Lynch Ed.  
Springer, en prensa (2009). 


316) Argilés, J.M., Oliván, M., Busquets, S. & López-Soriano, F.J.
Nutrition and cachexia
In “Supportive Care in Respiratory Disease” S.H. Amedzhai, D. Baldwin & D. Currow Eds., en prensa (2010) (CL)


317) Argilés, J.M., Busquets, S., Toledo, M. and López-Soriano, F.J.
Pro-inflammatory cytokines and their actions on the metabolic disturbances associated with cancer: implications in cachexia
Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry, en prensa (2010) (R)


318) Figueras, M., Olivan, M., Busquets, S., López-Soriano, F.J. & Argilés, J.M.
Effects of eicosapentaenoic acid (EPA) treatment on an animal model of diabetes: an improvement of the inflammatory status?
Obesity, en prensa (2010) (A)


319) Argilés, J.M., Fontes de Oliveira, C.C., Fuster, G., Ametller, E.,  Figueras, M.T., Olivan, M., López-Soriano-F.J., Isfort, R.J. & Busquets, S. 
CFR2 agonists on cachexia in tumour-bearing rats: patterns of gene expression in muscle and fat.
Muscle and Nerve, en prensa (2010) (A)


320) Ametller, E., Busquets, S., Fuster, G., Figueras, M.T., Fontes de Oliveira, C.C., Silva, P., Argilés, J.M. & López-Soriano, F.J.
Effects of formoterol on protein metabolism in C2C12 myotubes during hyperthermia.
Muscle and Nerve, en prensa (2010) (A)


321) Toledo, M., Busquets, S., Sirisi, S., Serpe, R., Orpi, M., Coutinho, J., Martínez, R.,  López-Soriano, F.J. & Argilés, J.M.
Cancer cachexia: physical activity and grip force in tumour-bearing rats.
Oncology Reports,  en prensa (2010) (A)


322) Busquets, S., Serpe, R., Sirisi, S., Toledo, M., Coutinho, J., Martínez, R., Orpi, M., López-Soriano, F.J. & Argilés, J.M.
Acetate of megestrol: new evidences supporting its use in cancer cachexia. An experimental study.
Clinical Nutrition,  en prensa (2010) (A)


323) Ametller, E., Busquets, S., Fuster, G., Figueras, M.T., Fontes de Oliveira, C.C., Sette, A., Barbaris, P., Argilés, J.M. & López-Soriano, F.J.
Effects of formoterol on muscle regeneration in cancer cachexia.
Sometido/Submitted


324) Fuster, G., Almendro, V., Fontes de Oliveira, C.C., Busquets, S., López-Soriano, F.J. & Argilés, J.M.
IL-15 influences differentiation and apoptosis in adipocytes: implications in obesity handling.
Sometido/Submitted


325) Van Norren, K., Faber, J., Kegler, D.,  Argilés, J.M., van de Heijning, B, Deutz, N.E.P., Laviano, A. & van Helvoort, A.
Fish oil and leucine-induced decreases in plasma calcium in tumor-bearing mice correlate with increases in exvivo muscle function and daily activity.
Sometido/Submitted


326) Seelaender, M., Carrari, C.C., Ojeda, M.P.A., Oliveira, CCF, Toledo, M., Sirisi, S, Batista jr. M. & Argilés, J.M.
Adipose tissue inflammation in cachexia: effect of endurance training.
Sometido/Submitted


327) Olivan, M., Busquets, S., Figueras, M.T., Fontes de Oliveira, C.C., Sette, A., Ventura da Silva, P.,  López-Soriano, F.J. & Argilés, J.M.
Different nutraceuticals are able to inhibit muscle proteolysis in vitro.
Sometido/Submitted


328) Olivan, M.,  Figueras, M.T., Busquets, S., Fontes de Oliveira, C.C., Ventura da Silva, P., Sette, A., Hartmann, A., Springer, J., Anker, S.D., López-Soriano, F.J. & Argilés, J.M.
Anticachectic effects of theofylline: a nutraceutical for the potential treatment of muscle wasting.
Sometido/Submitted


329) Argilés, J.M., López-Soriano, F.J., Toledo, M. & Busquets,
The cachexia score: a new tool for the staging of cancer patients.
Sometido/Submitted


330) Busquets, S., Toledo, M., Sirisi, S., Orpi, M., Serpe, R., Coutinho, J., Martínez, R.,  López-Soriano, F.J. & Argilés, J.M.
Formoterol and cancer wasting in rats: effects on muscle force and total physical activity.
Sometido/Submitted


331) Springer, J., Tschirner, A., Hartmann, K., Palus, S., Wirth, E.K., Busquets, S., Argilés, J.M., von Harsdorf, R., Köhrle, J., Adams, V., Anker S.D. & Doehner, W.
Inhibition of xanthine oxidase reduces wasting and improves outcome in experimental cancer cachexia.
Sometido/Submitted


332) Morley, J.E., Argiles, J.M., Evans, W.J., Bhasin, S., Cella, D., Deutz, N.E.P., Doehner, W., Fearon, K.C.H., Ferrucci, L., Guralnik, J.M., Hellerstein, M.K., Kalantar-Zadeh, K., Lochs, H., MacDonald, N., Mulligan, K., Muscaritoli, M., Ponikowski, P., Posthauer, M.E., Rossi Fanelli, F., Schambelan, M.,  Schols, A.M.W.J., Schuster, M.W., Anker, S.D.
Nutritional recommendations for patients with cachexia.
Sometido/Submitted


333) Fontes de Oliveira, C.C, Constantinou, C., Mintzopoulos, D.,  He, J., Kesarwani, M.,Mindrinos, M., Rahme, L.G., Durfort, M., López-Soriano, F.J.,  Busquets, S., Argilés, J.M., and A. Tzika, A.
NMR in conjunction with Morphological and Functional Genomics Studies suggest Mitochondrial Dysfunction in a Murine Model of Cancer Cachexia
Sometido/Submitted




(A) = Article/Artículo
(R) = Review/Revisión
(CL) = Book Chapter/Capítulo libro
(L) = Book/Libro